SS-31 Peptide Vial

SS-31 Peptide: A Mitochondria-Targeted Antioxidant Peptide Ushering in a New Era of Anti-Aging.

SS-31 (also known as Elamipretide) is a mitochondria-targeted tetrapeptide composed of four amino acids (D-Arg-dimethylTyr-Lys-Phe-NH₂). With its unique cationic and aromatic structure, it can actively cross cell membranes and selectively localize to the inner mitochondrial membrane. It was originally designed to protect mitochondrial structure, enhance energy metabolism, and counteract oxidative stress and apoptosis.

Unlike traditional antioxidants, SS-31 does not simply "scavenge" free radicals. Instead, it stabilizes mitochondrial membrane lipids-particularly cardiolipin-thereby optimizing mitochondrial function at its source and preventing excessive production of ROS (reactive oxygen species). This mechanism enables it to achieve true anti-aging effects at the cellular level.

Mechanism of Action: Targeting Mitochondria to Protect the Cell's Energy Powerhouse at Its Source

Mitochondria are the cell's energy factories and also the primary site of free radical production. The mechanisms of SS-31 mainly include the following:

• Targeting Cardiolipin

SS-31 binds to cardiolipin, a unique phospholipid located in the inner mitochondrial membrane, preventing its oxidative damage and thereby preserving the integrity and function of the mitochondrial membrane.

• Enhancing ATP Synthesis Efficiency

By optimizing the stability of complexes within the electron transport chain (ETC), SS-31 reduces electron leakage and improves the efficiency of cellular energy metabolism.

• Reducing Excessive ROS Production

Through structural stabilization and functional optimization, SS-31 decreases the generation of reactive oxygen species (ROS) at the source, rather than relying on external free radical scavenging.

• Anti-Inflammatory and Anti-Apoptotic Effects

SS-31 inhibits mitochondria-mediated cell death pathways (such as cytochrome c release) and helps alleviate chronic inflammatory responses, contributing to the delay of degenerative diseases.

Research Evidence: Therapeutic Potential Across Multiple Diseases and Aging Conditions

In recent years, SS-31 (Elamipretide) has demonstrated significant effects in various disease models, spanning the cardiovascular system, kidneys, neurodegenerative eye disorders, and age-related muscle decline:

SS-31 (Elamipretide) has advanced into multiple stages of clinical trials. It has received orphan drug designation from the U.S. Food and Drug Administration (FDA) for rare mitochondrial diseases, optic neuropathies, and heart failure. Although it remains under drug development, SS-31 has emerged as a major research focus in anti-aging and mitochondrial optimization, with considerable therapeutic potential.

Safety Profile

Current clinical observations suggest that SS-31 is generally well tolerated, with relatively mild reported side effects. However, the long-term safety of prolonged use still requires further investigation and confirmation through larger, long-term clinical studies.

Conclusion: A New Generation of Mitochondrial Nutritional Intervention

SS-31 (Elamipretide) represents the convergence of modern mitochondrial science and precision medicine. Rather than serving as a simple antioxidant, it focuses on the fundamental repair and protection of the cell's "energy core" - the mitochondria.

Its success could potentially reshape our understanding of "anti-aging," cellular health, and even the reversal of chronic diseases.

Looking ahead, SS-31 may be used synergistically with NAD⁺ boosters (such as NMN and NR), SOD mimetics, and ubiquitin pathway modulators to build a next-generation mitochondrial support system - paving the way toward more effective strategies for slowing the aging process.

Xi'an Ruichi Biotech Co., Ltd. is an innovative life science company providing dietary supplements, custom synthesis. We also provide OEM and private label services, including custom logo and packaging options, to meet your branding needs. Dosage forms including powder, capsules,softgels, tablets. As an FDA-registered manufacturer, we are committed to improving human health through consistent quality, regulatory compliance, and sustainable growth. We manufacture and source a broad portfolio of dietary supplements and health ingredient raw materials for global markets.

Quality is embedded in every stage of our operations. All manufacturing activities are conducted under strict supervision, following validated processes and standardized procedures. Our facilities operate in full compliance with GMP requirements, ensuring that every product meets international quality and safety standards. We maintain a comprehensive system of documented SOPs, aligned with GMP guidelines and ISO 9001:2015 certification, to support reliability, traceability, and continuous improvement.

Our quality management system integrates ISO 9001:2015 and GMP standards, enabling us to deliver products and services that meet the expectations of global pharmaceutical and nutraceutical markets. All products are tested in accordance with leading pharmacopeial standards, including CP, BP, EP, and USP. Every batch is freshly manufactured, with a typical shelf life of 2–3 years, ensuring optimal stability and performance.

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We can provide customized packaging according to your requirement.

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