What is Tianeptine Sodium Salt ?
Tianeptine sodium is the salt form of tianeptine and is the clinically used active pharmaceutical ingredient. It is primarily indicated for the treatment of major depressive disorder in adults, particularly when accompanied by anxiety symptoms.
Product specification
| Product Name | Tianeptine Sodium Salt |
| Form | White powder |
| CAS | 30123-17-2 |
| Specification | 99% |
| EINECS No. | 250-059-3 |
| Molecular Formula | C21H24ClN2NaO4S |
| Molecular Weight | 458.93g/mol |
| Shelf Life | 2 Years Proper Storage |
quality control
| Testing Items | Specifications | Results |
| Description | White crystal powder | White crystal powder |
| Solubility | soluble In Dimethylformamide,insoluble in water and dichloromethane | Complies |
| Identification | (1)¹HNMR conforms to structure(2)It gives reaction of sulfate | Complies |
| Water | ≤ 5.0% | 3.9% |
| Assay | 98.0%-101.0% (On anhydrous basis ) | 98.66% |
| Conclusion | This product conforms to in-house standard. | - |
What is the Core Characteristics of Tianeptine Sodium Salt?
Advantages of the Salt Form
Tianeptine itself has relatively poor water solubility. Converting it into the sodium salt significantly improves its water solubility, allowing for better absorption in the body and a faster onset of action. This enhanced solubility also facilitates formulation into oral dosage forms, such as tablets.
Does Tianeptine Sodium Salt's Pharmacological Effects Consistent with Tianeptine?
Its mechanism of action involves modulation of serotonin (5-HT) reuptake in the brain and improvement of neuroplasticity. This helps alleviate core symptoms of depression, such as persistent low mood and loss of interest.
In addition, it has minimal impact on cognitive function and is less likely to cause pronounced side effects such as significant sedation or weight gain.
What is the Mechanisms of Action of Tianeptine Sodium Salt?
From a mechanistic perspective, tianeptine sodium exerts its antidepressant effects primarily by modulating the brain's monoaminergic neurotransmitter systems. Research suggests that it selectively enhances the reuptake of serotonin (5-HT) in the prefrontal cortex, while reducing glutamate release in the hippocampus under stress conditions.
This dual regulatory action enables it to alleviate depressive symptoms while also providing protective effects on cognitive function.
What are the Eeffects of Tianeptine Sodium Salt ?
It can be divided into two main categories: pharmacological effects and clinical therapeutic effects, as detailed below:
Core Pharmacological Effects
1. Regulates the reuptake of serotonin (5-HT) in the central nervous system, precisely modulating its synaptic cleft concentration and improving neurotransmitter imbalance in the brain.
2. Promotes neuroplasticity in brain regions such as the hippocampus, protects neurons, repairs damaged synaptic connections, and helps restore normal emotional regulation pathways.
3. Mildly modulates the hypothalamic–pituitary–adrenal (HPA) axis, reducing neuroendocrine dysregulation associated with depression and anxiety.
Clinical Therapeutic Effects
1. Primarily used for the treatment of major depressive disorder in adults, helping to relieve core depressive symptoms such as persistent low mood, loss of interest, slowed thinking, and feelings of guilt or worthlessness.
2. Improves anxiety symptoms associated with depression and demonstrates good synergistic effects in patients with comorbid depression and anxiety.
3. Compared with some other antidepressants, it has less impact on cognitive function (e.g., attention and memory), helping patients better maintain their daily work and learning abilities.
application
| Application Area | Product Form | Main Applications |
| Mental Health & Mood Support | Raw material powder, research-grade products, formulation development ingredients | Used in the research and development of products related to mood regulation, stress management, and mental health support |
| Antidepressant Research | API raw materials, experimental research materials | Used in neuroscience research, including studies on mood disorders, depressive conditions, and related neurotransmitter regulation mechanisms |
| Neurotransmitter Regulation Research | Research-grade compounds | Used to investigate glutamate system regulation, neuroplasticity, and mechanisms involved in brain function modulation |
| Cognitive Health | Ingredients for formulation research | Used to explore cognitive function, attention, and brain health support under stress-related conditions |
| Stress Management Product Development | Functional health product raw materials | Used in research on emotional balance and neurological adaptation mechanisms under long-term stress conditions |
| Neuroscience Research | High-purity research materials | Used as a neuropharmacological research tool for studying receptor interactions, synaptic plasticity, and brain function |
| Pharmaceutical Development | API intermediates / pharmaceutical raw materials | Used for drug development, quality research, and related pharmaceutical formulation development |
FAQ
Q: What is Tianeptine Sodium Salt?
A: Tianeptine Sodium Salt is a research-grade antidepressant and nootropic compound that supports mood regulation, stress management, and cognitive function. Unlike traditional SSRIs, it works primarily through modulating glutamate and enhancing neuroplasticity, providing a unique mechanism for mood and brain health research.
Q: How does Tianeptine Sodium Salt work?
A: Tianeptine Sodium Salt interacts with the glutamatergic system, enhancing synaptic plasticity and neuronal resilience. This mechanism helps improve mood, reduce anxiety, and support cognitive performance. It also affects the μ-opioid receptors, which may contribute to its anxiolytic and mood-enhancing effects.
Q: What are the main benefits of Tianeptine Sodium Salt?
A: 1.Mood Support & Antidepressant Research: Helps regulate emotional balance in research models
2.Stress Reduction: Supports resilience to acute and chronic stress
3.Cognitive Enhancement: May improve focus, learning, and memory in research studies
4. Neuroprotective Effects: Promotes synaptic plasticity and brain health
Q: Is Tianeptine Sodium Salt safe?
A: Generally safe for research purposes when handled correctly
Side effects in human studies may include mild gastrointestinal discomfort or headache
Always use according to research protocols and consult professionals
If you want to buy Tianeptine Sodium Salt ,pls feel free to contact Xi'an Ruichi Biotech Co., Ltd. Enhance your research into mood regulation, stress resilience, and cognitive health with Tianeptine Sodium Salt – a potent, research-grade compound for neuroscience and pharmacology studies.
E-mail: Jenny@ruichibio.com
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