What is Palmitoylethanolamide PEA Powder?
Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide and endogenous lipid mediator widely recognized for its anti-inflammatory, analgesic, and neuroprotective properties.
As a member of the N-acylethanolamine (NAE) family, PEA is produced in the body in response to stress, inflammation, and pain, helping restore physiological balance.
With increasing demand in dietary supplements, pharmaceuticals, and cosmeceuticals, PEA has become a key functional ingredient for pain management and inflammation control.
| Appearance | White Powder |
| Specification | 99% |
| CAS | 544-31-0 |
| Molecular Formula | C18H37NO2 |
| Molecular Weight | 299.28 g/mol |
| Packaging | Drum,Vacuum Packed,Aluminum Foil Bag |
| Shelf Life | 2 Years Proper Storage |
| For research use only |
What Are the Mechanism of Action of Palmitoylethanolamide?
PEA works through multiple biological pathways:
PPAR-α Activation
PEA is a potent agonist of Peroxisome Proliferator-Activated Receptor Alpha (PPAR-α), which:
Reduces inflammatory gene expression
Regulates lipid metabolism
Controls neuroinflammation
Mast Cell Stabilization
PEA inhibits mast cell degranulation, reducing:
Histamine release
Local inflammation
Pain signaling
Cytokine Modulation
Downregulates pro-inflammatory cytokines such as TNF-α and IL-6
Helps control chronic inflammation
Endocannabinoid System Support
Although PEA does not directly bind to CB1/CB2 receptors, it enhances endocannabinoid activity through the "entourage effect", improving overall pain modulation.
What Are the Benefits of Palmitoylethanolamide Powder?
✔Supports chronic pain relief (neuropathic & inflammatory pain)
✔ Powerful anti-inflammatory activity
✔ Promotes nerve protection and recovery
✔ Helps regulate immune response
✔ Non-psychoactive & non-addictive
✔ Excellent safety and tolerability profile
What are the Applications of Palmitoylethanolamide Powder?
● Dietary Supplements
1.Joint health formulas
2.Pain relief capsules
3.Anti-inflammatory blends
●Pharmaceutical & Research Use
1.Neuropathic pain studies
2.Neuroprotection research
●Cosmetic & Skincare
1.Sensitive skin care
2.Anti-redness formulations
3.Barrier repair products
Who are we?
Xi'an Ruichi Biotech Co., Ltd. is an innovative life science company providing dietary supplements, custom synthesis. We also provide OEM and private label services, including custom logo and packaging options, to meet your branding needs. Dosage forms including powder, capsules,softgels, tablets. As an FDA-registered manufacturer, we are committed to improving human health through consistent quality, regulatory compliance, and sustainable growth. We manufacture and source a broad portfolio of dietary supplements and health ingredient raw materials for global markets.
Quality is embedded in every stage of our operations. All manufacturing activities are conducted under strict supervision, following validated processes and standardized procedures. Our facilities operate in full compliance with GMP requirements, ensuring that every product meets international quality and safety standards. We maintain a comprehensive system of documented SOPs, aligned with GMP guidelines and ISO 9001:2015 certification, to support reliability, traceability, and continuous improvement.
Our quality management system integrates ISO 9001:2015 and GMP standards, enabling us to deliver products and services that meet the expectations of global pharmaceutical and nutraceutical markets. All products are tested in accordance with leading pharmacopeial standards, including CP, BP, EP, and USP. Every batch is freshly manufactured, with a typical shelf life of 2–3 years, ensuring optimal stability and performance.
Logistics Update
To ensure that customers receive their goods smoothly,we supply all kinds of couriers according to different needs.Like DHL, FedEx, UPS, EMS, TNT, by Sea, by Air.
We can provide customized packaging according to your requirement.
Payment method
Certification:
FAQ
Q: What is Palmitoylethanolamide (PEA) Powder?
A: Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide known for its anti-inflammatory, analgesic, and neuroprotective properties. As a high-purity powder, it is widely used in nutraceuticals, dietary supplements, and biomedical research.
Q: How does PEA work?
A: PEA works by interacting with the endocannabinoid system and modulating mast cell activity, leading to:
Reduction of chronic and acute inflammation
Pain relief in neuropathic conditions
Neuroprotective effects supporting cognitive and nerve health
Enhanced cellular resilience and tissue protection
This makes it ideal for pain management, neuroprotection, and anti-inflammatory supplement development.
Q: What are the main applications of PEA Powder?
A: Nutraceuticals and dietary supplements – capsules, tablets, powders
Pain management and joint health products
Neuroprotection and cognitive support formulations
Biomedical research in inflammation and neuropathic pain
Functional foods and beverages targeting cellular health
Q: What are the key advantages of PEA API?
A: Natural, Bioactive Fatty Acid Amide – Supports healthy inflammatory response
Neuroprotective & Analgesic Effects – Clinically studied
High-Purity, Stable Powder – Suitable for capsules, tablets, and functional drinks
Research-Grade Quality – Ensures reproducible results in experiments
Versatile Applications – From supplements to preclinical research
If you want to buy Palmitoylethanolamide Powder, pls feel free to contact Xi'an Ruichi Biotech Co., Ltd. Develop high-performance anti-inflammatory, neuroprotective, and joint support supplements with premium Palmitoylethanolamide (PEA) Powder – trusted purity, stable, and ready for advanced applications.
E-mail: Jenny@ruichibio.com
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