Pure Urolithin A

Urolithin A (UA) is a naturally occurring compound that belongs to the polyphenol family. It is produced in the human gut through microbial metabolism of plant tannins consumed in the diet. Urolithin A exhibits multiple biological activities, including antioxidant, anti-cancer, anti-inflammatory, and anti-aging effects.

The primary dietary sources of UA precursors include pomegranates, grapes, nuts, and various berries. In the body, gut microbiota convert ellagic acid and ellagitannins from these foods into Urolithin A.

Research indicates that Urolithin A can extend mitochondrial lifespan, promote cellular renewal, and exert significant anti-aging effects. In addition, it has demonstrated protective benefits for the nervous system, gastrointestinal system, and cardiovascular system. Recent studies suggest that supplementation with Urolithin A may help reverse age-related decline in hematopoietic stem cells and immune function, offering promising strategies for addressing age-associated health conditions.

However, not everyone is able to efficiently produce Urolithin A from dietary sources due to individual differences in gut microbiota composition. While synthetically produced Urolithin A has been shown to be safe, regulatory approval and dietary use policies vary by country. As research continues to advance, direct oral supplementation of UA may become a more widely accessible approach for supporting healthy aging.

Urolithin A (UA) provides multiple health benefits, including anti-inflammatory, antioxidant, and anti-aging effects. It activates mitophagy and improves mitochondrial function, thereby helping to slow specific aging-related processes.

1. Anti-Aging Through Mitophagy Activation

UA specifically combats aging by activating mitochondrial autophagy (mitophagy), promoting the removal of damaged mitochondria and improving cellular energy metabolism.

In the context of aging, it has been shown to enhance muscle function and potentially reverse age-related decline in hematopoietic stem cells and immune system function.

2. Anti-Inflammatory and Neuroprotective Effects

UA exhibits anti-inflammatory and neuroprotective properties, contributing to the reduction of chronic systemic inflammation and supporting protection against neurodegenerative conditions.

3. Weight Management and Metabolic Support

UA has been shown to help prevent and potentially reverse high-fat diet–induced obesity by improving metabolic function. It promotes thermogenesis in brown adipose tissue and induces browning of white adipose tissue, thereby increasing energy expenditure and supporting fat loss. Importantly, current research indicates these effects occur without significant adverse effects under studied conditions.

4. Reduction of Skin Aging

A 2023 human clinical study demonstrated that topical application of UA significantly reduced wrinkles, improved skin hydration, and decreased UV-induced erythema.

UA upregulates collagen synthesis pathways, inhibits collagen degradation, and enhances mitophagy and autophagy in skin cells. These findings support its potential use in maintaining skin health and preventing skin aging and UVB-induced photodamage.

Xi'an Ruichi Biotech Co., Ltd. is an innovative life science company providing dietary supplements, custom synthesis. We also provide OEM and private label services, including custom logo and packaging options, to meet your branding needs. Dosage forms including powder, capsules, softgels, tablets. As an FDA-registered manufacturer, we are committed to improving human health through consistent quality, regulatory compliance, and sustainable growth. We manufacture and source a broad portfolio of dietary supplements and health ingredient raw materials for global markets.

Quality is embedded in every stage of our operations. All manufacturing activities are conducted under strict supervision, following validated processes and standardized procedures. Our facilities operate in full compliance with GMP requirements, ensuring that every product meets international quality and safety standards. We maintain a comprehensive system of documented SOPs, aligned with GMP guidelines and ISO 9001:2015 certification, to support reliability, traceability, and continuous improvement.

Our quality management system integrates ISO 9001:2015 and GMP standards, enabling us to deliver products and services that meet the expectations of global pharmaceutical and nutraceutical markets. All products are tested in accordance with leading pharmacopeial standards, including CP, BP, EP, and USP. Every batch is freshly manufactured, with a typical shelf life of 2–3 years, ensuring optimal stability and performance.

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