What is 17α-Hydroxyprogesterone Powder?
17α-Hydroxyprogesterone (17-OHP) is an endogenous progestogen and a key intermediate in the biosynthesis of steroid hormones.
It plays a critical role in cortisol and sex hormone production, particularly in the adrenal cortex and gonads. Clinically, serum 17-OHP levels serve as a primary biomarker for congenital adrenal hyperplasia (CAH), especially 21-hydroxylase deficiency. Its structural specificity-featuring a hydroxyl group at the C17α position-enables selective receptor binding and enzymatic conversion. As a research-grade compound, it supports mechanistic studies in endocrinology, enzyme kinetics, and diagnostic assay development.
What is the Mechanisms of Action of 17α-Hydroxyprogesterone Powder?
Biological Functions and Mechanism of Action
- Endogenous Progestogen:
Secreted by the adrenal glands and gonads, it participates in the regulation of the menstrual cycle and the development of the female reproductive system.
- Hormone Precursor:
It is an important intermediate in the synthesis of cortisol, androstenedione, testosterone, and estrogens.
- Receptor Activity:
Acts as a progesterone receptor (PR) agonist, with effects similar to progesterone.
Functions as a mineralocorticoid receptor (MR) antagonist.
Acts as a weak partial agonist of the glucocorticoid receptor (GR), with potency far lower than cortisol.
Clinical Applications
Previously used for the prevention of preterm birth, especially in high-risk women with a history of preterm delivery; however, its use has become restricted due to potential teratogenic risks.
Used in the treatment of recurrent miscarriage, dysfunctional uterine bleeding, and endometriosis.
Not recommended for routine contraception, as it lacks estrogenic activity and is associated with relatively frequent side effects.
What are the Applications of 17α-Hydroxyprogesterone Powder?
Safety and Precautions
Contraindications:
Patients with acute or chronic hepatitis or nephritis
Individuals with a history of thrombotic disorders
Breastfeeding women or those with breast masses
Use with caution in patients with uterine fibroids or hypertension
Common Adverse Reactions:
Menstrual irregularities (prolonged menstruation, irregular bleeding, etc.)
Nausea, dizziness, fatigue, breast tenderness
Discontinue immediately in cases of severe allergic reactions or development of breast lumps
Drug Interactions:
Enzyme inducers (such as carbamazepine and phenytoin) may accelerate its metabolism and reduce therapeutic efficacy
May inhibit the metabolism of cyclosporine, increasing its plasma concentration and the risk of toxicity
FAQ
Q: What is 17α-Hydroxyprogesterone Powder?
A: 17α-Hydroxyprogesterone (17-OHP) is a synthetic steroid hormone and a key intermediate in the biosynthesis of glucocorticoids and sex hormones. It is widely used in research to study hormonal pathways, reproductive health, and metabolic regulation.
Q: How does 17α-Hydroxyprogesterone work?
A: 17α-Hydroxyprogesterone is a precursor in the steroidogenesis pathway, converting into important hormones such as cortisol, progesterone, and androgens. This makes it valuable for research into:
- Endocrine function and hormone balance
- Reproductive health studies
- Metabolic and adrenal regulation
It acts on the hypothalamic-pituitary-adrenal (HPA) axis to help model hormone synthesis and regulation in research.
Q: What are the main benefits of 17α-Hydroxyprogesterone Powder in research?
A: 1.Hormone Pathway Research: Study steroidogenesis and endocrine regulation
2.Reproductive Health Studies: Investigate progesterone-related functions
3.Metabolic Research: Examine cortisol production and adrenal function
4.Research-Grade Compound: Suitable for in vitro and in vivo studies
Q: Is 17α-Hydroxyprogesterone Powder safe?
A: 1.Considered safe for research use under controlled conditions
2.Minimal side effects in in vitro or in vivo studies when handled properly
3.Always follow research protocols and laboratory safety guidelines
If you want to buy 17α-Hydroxyprogesterone Powder, pls feel free to contact Xi'an Ruichi Biotech Co., Ltd. Enhance your research into hormone pathways, reproductive health, and metabolism with 17α-Hydroxyprogesterone Powder – a potent, research-grade steroid for advanced endocrine and metabolic studies.
E-mail: Jenny@ruichibio.com
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